PROTEIN AND LIPID BINDING OF VOLATILE ANAESTHETIC AGENTS
نویسندگان
چکیده
منابع مشابه
Respiratory and Circulatory Factors in Uptake and Distribution of Volatile Anaesthetic Agents.
Inhalation anaesthesia may be viewed as the development of a series of tension gradients. The high partial pressures delivered by the anaesthetic apparatus progressively decrease on their passage through the circuit, from circuit to alveoli, from alveoli to bloodstream, and finally from circulation to brain or other tissues. The development of these gradients determines the course of anaesthesi...
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NK cell cytotoxicity against the erythroleukaemia cell line K562 was studied, during and after the in vitro exposure to clinically-used concentrations of the general anaesthetic agents nitrous oxide, halothane and enflurane. Each of these agents produced a dose-dependent reduction in cytotoxicity. At approximately equipotent doses nitrous oxide produced less suppression than either halothane or...
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Laryngospasm and apnoea or alterations in the rhythm of respiration have been produced in decerebrate preparations of cats and in cats anaesthetized with chloralose during the start of inhalation of volatile anaesthetic agents. Ether, halothane and methoxyflurane all produced these effects when they were placed in contact with the larynx. The responses to ether occurred more rapidly than those ...
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In evaluating any newly introduced anaesthetic, it is worth comparing its properties with those of a theoretical “ideal” volatile agent which would have a low solubility in blood to allow for rapid equilibration between delivered concentration and the effect site in the central nervous system (CNS). This would facilitate rapid induction of anaesthesia, allow easier titration of anaesthetic dose...
متن کاملToxicity of inhalation anaesthetic agents.
Although hundreds of compounds on the chemist's shelf are known to produce anaesthesia, relatively few are used clinically. The requirements for a clinically useful anaesthetic agent are necessarily stringent and include: a wide margin of safety, total reversibility of anaesthetic effect and an absence of long-term toxicity. In addition, a successful inhalation anaesthetic agent must combine th...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1964
ISSN: 0007-0912
DOI: 10.1093/bja/36.3.150